Many previous clinical studies have documented the benefits of electrical stimulation to enhancing osseointegration. What is new is precise control of specific protein expressions to improve results.
Scientific Related Articles

Nerve electrical stimulation enhances osseointegration of implants in the beagle – Click Here

SDF-1 Enhances Wound Healing of Critical-Sized Calvarial Defects beyond Self-Repair Capacity – Click Here


Sci Rep. 2019 Mar 20;9(1):4916. doi: 10.1038/s41598-019-41471-z Link
Nerve electrical stimulation enhances osseointegration of implants in the beagle.
Zhou P1,2, He F1, Liu B3, Wei S4,5.
Author information
Dental implantation has been the primary method for the treatment of tooth loss, but longer than 3 months healing times are generally required. Because immediate load implants are suitable only for certain categories of implant patients, it has value to develop a novel method to facilitate the implant-bone osseointegration process. Cylindrical titanium implants were implanted in the tooth sockets of beagles, and microelectrode stimulation of the sympathetic nerves in the infraorbital nerve was performed after implantation for 1 week. The authors found that one-sided nerve stimulation was shown to evoke consistent electric potential changes in both sides of the infraorbital nerves. Moreover, after 4 weeks of implantation, more new bone was clearly observed around the implants in the beagles that received electrical stimulation treatment than was observed in the control animals. Furthermore, a higher mineralization density was measured in the new peri-implant bone tissues of the stimulated beagles when compared to controls. These results demonstrate that the simple and safe physical method of microelectrode stimulation to sympathetic nerves can promote the formation of new bone and the osseointegration of implants. This technique is worth promoting and has the potential to reduce the healing time of dental implantation in future clinical cases.
PMID: 30894667 PMCID: PMC6427028 DOI: 10.1038/s41598-019-41471-z

A number of OPG injection papers have demonstrated that OPG enhances Osseointegration and implant healing. What is new is bioelectric controlled release of OPG instead of injections.

The effect of osteoprotegerin on implant osseointegration in … › pmc › articles › PMC5332467
by Y Liu – ‎2017 – ‎Cited by 8 – ‎Related articles
Jan 25, 2017 – Systemic administration of OPG improved implant osseointegration and fixation in ovariectomized rats, resulting from the increased peri-implant …

The administration of OPG improved titanium screw fixation in OVX rats after 8-week treatment. The enhancement of implant fixation was related to the increase of peri-implant bone density, improved trabecular microarchitecture, and enhanced implant osseointegration.

A number of electromagnetic filed therapy papers have demonstrated enhanced osseointegration and implant healing. What is new frequency specific electromagnetic fields for precise controlled release of specific bone regeneration and osseointegration promoting proteins.

Gerodontology. 2012 Jun;29(2):e1249-51. doi: 10.1111/j.1741-2358.2011.00525.x.
Effect of electromagnetic field on bone regeneration around dental implants after immediate placement in the dog mandible: a pilot study.

do Nascimento C1, Issa JP, Mello AS, de Albuquerque Junior RF.
Author information
Faculty of Dentistry of Ribeirão Preto, Department of Dental Materials and Prosthodontics, University of São Paulo, São Paulo, Brazil.
Accelerating bone healing around dental implants can reduce the long-term period between the insertion of implants and functional rehabilitation.
This in vivo study evaluated the effect of a constant electromagnetic field (CEF) on bone healing around dental implants in dogs.
Eight dental implants were placed immediately after extraction of the first pre-molar and molar teeth on the mandible of two male dogs and divided into experimental (CEF) and control groups. A CEF at magnetic intensity of 0.8 mT with a pulse width of 25 μs and frequency of 1.5 MHz was applied on the implants for 20 min per day for 2 weeks.
After qualitative histological analysis, a small quantity of newly formed bone was observed in the gap between the implant surface and alveolar bone in both groups.